产品名称
ECEL1 Rabbit Polyclonal Antibody
别名
Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein)
基因名称
ECEL1 XCE UNQ2431/PRO4991
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.360% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9427
Human Swissprot No.
O95672
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95672/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13599
Mouse Swissprot No.
Q9JMI0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JMI0
Rat Gene Link
https://www.uniprot.org/uniprot/60417
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JHL3
免疫原
Synthesized peptide derived from human ECEL1 AA range: 200-250
特异性
This antibody detects endogenous levels of ECEL1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the M13 family of endopeptidases. Members of this family are zinc-containing type II integral-membrane proteins that are important regulators of neuropeptide and peptide hormone activity. Mutations in this gene are associated with autosomal recessive distal arthrogryposis, type 5D. This gene has multiple pseudogenes on chromosome 2. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014],
组织表达
Highly expressed in the CNS, in particular in putamen, spinal cord, medulla and subthalamic nucleus. A strong signal was also detected in uterine subepithelial cells and around renal blood vessels. Detected at lower levels in amygdala, caudate, thalamus, pancreas and skeletal muscle. Detected at very low levels in substantia nigra, cerebellum, cortex, corpus callosum and hippocampus.
细胞定位
Membrane ; Single-pass type II membrane protein .
功能
cofactor:Binds 1 zinc ion.,function:May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.,PTM:N-glycosylated.,similarity:Belongs to the peptidase M13 family.,tissue specificity:Highly expressed in the CNS, in particular in putamen, spinal cord, medulla and subthalamic nucleus. A strong signal was also detected in uterine subepithelial cells and around renal blood vessels. Detected at lower levels in amygdala, caudate, thalamus, pancreas and skeletal muscle. Detected at very low levels in substantia nigra, cerebellum, cortex, corpus callosum and hippocampus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
