产品名称
A Cyclase V/VI Rabbit Polyclonal Antibody
别名
ADCY5; Adenylate cyclase type 5; ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; ADCY6; KIAA0422; Adenylate cyclase type 6; ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitabl
蛋白名称
Adenylate cyclase type 5/6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=111
Human Swissprot No.
O95622/O43306
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95622/entry
Mouse Gene ID
224129/11512
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=224129
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64532
Rat Swissprot No.
Q04400/Q03343
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q04400
免疫原
The antiserum was produced against synthesized peptide derived from human ADCY5/6. AA range:931-980
特异性
A Cyclase V/VI Polyclonal Antibody detects endogenous levels of A Cyclase V/VI protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
组织表达
Detected in pancreas islets (at protein level). Detected in pancreas islets.
细胞定位
Cell membrane ; Multi-pass membrane protein. Cell projection, cilium .
信号通路
Purine metabolism;Chemokine;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;GnRH;Progesterone-mediated oocyte maturation;Melanogenesis;Dilated cardiomyopathy;
功能
catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Inhibition by calcium in the submicromolar concentration range.,function:This is a membrane-bound, calcium-inhibitable adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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