产品名称
A Cyclase IV Rabbit Polyclonal Antibody
别名
ADCY4; Adenylate cyclase type 4; ATP pyrophosphate-lyase 4; Adenylate cyclase type IV; Adenylyl cyclase 4
蛋白名称
Adenylate cyclase type 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=196883
Human Swissprot No.
Q8NFM4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8NFM4/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=104110
Mouse Swissprot No.
Q91WF3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91WF3
Rat Swissprot Link
http://www.uniprot.org/uniprot/P26770
免疫原
The antiserum was produced against synthesized peptide derived from human ADCY4. AA range:195-244
特异性
A Cyclase IV Polyclonal Antibody detects endogenous levels of A Cyclase IV protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010],
组织表达
Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level).
细胞定位
Cell membrane ; Multi-pass membrane protein . Cytoplasm .
信号通路
Purine metabolism;Calcium;Chemokine;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Taste transduction;GnRH;Progesterone-mediated oocyte maturation;Melanogenesis;Dilated cardiomyopathy;
功能
catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex.,function:This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
