产品名称
A Cyclase I Rabbit Polyclonal Antibody
别名
ADCY1; Adenylate cyclase type 1; ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase
蛋白名称
Adenylate cyclase type 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107
Human Swissprot No.
Q08828
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q08828/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=432530
Mouse Swissprot No.
O88444
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88444
免疫原
The antiserum was produced against synthesized peptide derived from human ADCY1. AA range:231-280
特异性
A Cyclase I Polyclonal Antibody detects endogenous levels of A Cyclase I protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
组织表达
Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla.
细胞定位
Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Membrane raft . Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. .
信号通路
Purine metabolism;Calcium;Chemokine;Oocyte meiosis;Vascular smooth muscle contraction;Gap junction;Long-term potentiation;GnRH;Progesterone-mediated oocyte maturation;Melanogenesis;Dilated cardiomyopathy;
功能
catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex.,function:This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,tissue specificity:Brain, retina and adrenal medulla.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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