BD-PT0017

4.1R Rabbit Polyclonal Antibody

EPB41; E41P; Protein 4.1; P4.1; 4.1R; Band 4.1; EPB4.1

常规抗体

EPB41

Protein 4.1

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

2035

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2035

P11171

http://www.uniprot.org/uniprotkb/P11171/entry

269587

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=269587

P48193

http://www.uniprot.org/uniprot/P48193

The antiserum was produced against synthesized peptide derived from human EPB41. AA range:626-675

4.1R Polyclonal Antibody detects endogenous levels of 4.1R protein.

WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

60kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009],

Brain,PCR rescued clones,Reticulocyte,Spleen,

Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Nucleus .

Tight junction;

disease:Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.,disease:Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.,function:Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.,PTM:O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.,PTM:Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.,PTM:Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.,similarity:Contains 1 FERM domain.,subunit:Binds with a high affinity to glycophorin and with lower affinity to band III protein. Associates with the nuclear mitotic apparatus. Binds calmodulin, CENPJ and DLG1. Also found to associate with contractile apparatus and tight junctions.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.