BD-PT0013

17β-HSD11 Rabbit Polyclonal Antibody

HSD17B11; DHRS8; PAN1B; PSEC0029; Estradiol 17-beta-dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lym

常规抗体

HSD17B11

Estradiol 17-beta-dehydrogenase 11

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

51170

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51170

Q8NBQ5

http://www.uniprot.org/uniprotkb/Q8NBQ5/entry

Q9EQ06

http://www.uniprot.org/uniprot/Q9EQ06

The antiserum was produced against synthesized peptide derived from human DHRS8. AA range:71-120

17β-HSD11 Polyclonal Antibody detects endogenous levels of 17β-HSD11 protein.

WB 1:500 - 1:2000. ELISA: 1:5000. IF 1:100-300 Not yet tested in other applications.

36kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009],

Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.

Endoplasmic reticulum . Lipid droplet . Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation. .

catalytic activity:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.,function:Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.,tissue specificity:Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.