BD-PT0012-14-3-3 σ Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

产品货号

BD-PT0012

产品名称

14-3-3 σ Rabbit Polyclonal Antibody

别名

SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin

类别

常规抗体

基因名称

SFN

蛋白名称

14-3-3 protein sigma

推荐应用

WB

反应种属

Human,Mouse

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

2810

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2810

Human Swissprot No.

P31947

Human Swissprot Link

http://www.uniprot.org/uniprotkb/P31947/entry

Mouse Gene ID

55948

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55948

Mouse Swissprot No.

O70456

Mouse Swissprot Link

http://www.uniprot.org/uniprot/O70456

免疫原

The antiserum was produced against synthesized peptide derived from human SFN. AA range:41-90

特异性

14-3-3 σ Polyclonal Antibody detects endogenous levels of 14-3-3 σ protein.

稀释度

IHC-p: 100-300.WB 1:500 - 1:2000. ELISA: 1:20000.. IF 1:50-200

预测分子量

30kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.,function:p53-regulated inhibitor of G2/M progression.,similarity:Belongs to the 14-3-3 family.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.,

组织表达

Present mainly in tissues enriched in stratified squamous keratinizing epithelium.

细胞定位

Cytoplasm. Nucleus . Secreted. May be secreted by a non-classical secretory pathway.

信号通路

Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;p53;Aldosterone-regulated sodium reabsorption;

功能

function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.,function:p53-regulated inhibitor of G2/M progression.,similarity:Belongs to the 14-3-3 family.,subcellular location:May be secreted by a non-classical secretory pathway.,subunit:Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.