产品名称
PACE1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57147
Human Swissprot No.
Q8IZE3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IZE3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/240880
Mouse Swissprot No.
Q9DBQ7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DBQ7
免疫原
Synthesized peptide derived from human PACE1 AA range: 519-569
特异性
This antibody detects endogenous levels of PACE1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012],
组织表达
Ubiquitously expressed.
细胞定位
Cytoplasm . Golgi apparatus . Cell projection, lamellipodium . Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.
功能
domain:The protein kinase domain is predicted to be catalytically inactive.,function:May play a role in regulating cell adhesion/migration complexes in migrating cells.,PTM:May be myristoylated; myristoylation may target it to Golgi compartment.,PTM:Phosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 4 HEAT repeats.,subcellular location:Colocalized with EZR/VIL2, actin and CD44 in lamellipodia.,subunit:Interacts with EZR/VIL2 C-terminal domain.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
