产品名称
Nuclear Receptor NR4A1 (Phospho-Ser351) Rabbit Polyclonal Antibody
别名
Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1;Nuclear hormone receptor NUR/77;Nur77;Orphan nuclear receptor HMR;Orphan nuclear receptor TR3;ST-59;Testicular receptor 3)
基因名称
NR4A1 GFRP1 HMR NAK1
蛋白名称
Nuclear Receptor NR4A1 (Phospho-Ser351)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
P22736
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P22736/entry
免疫原
Synthesized pospho peptide derived from human Nuclear Receptor NR4A1 (Phospho-Ser351)
特异性
This antibody detects endogenous pospho levels of human Nuclear Receptor NR4A1 (Phospho-Ser351)
稀释度
WB 1:500-2000, ELISA(peptide)1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],
组织表达
Fetal muscle and adult liver, brain and thyroid.
细胞定位
Nucleus . Cytoplasm . Mitochondrion . Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). .
功能
function:Orphan nuclear receptor.,induction:By growth-stimulating agents.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with GADD45GIP1.,tissue specificity:Fetal muscle and adult liver, brain and thyroid.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
