产品名称
MAP2 (Phospho-Thr1616) Rabbit Polyclonal Antibody
别名
Microtubule-associated protein 2 (MAP-2)
蛋白名称
MAP2 (Phospho-Thr1616)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
P11137
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P11137/entry
Rat Swissprot Link
Human:T1616, Mouse:T1620, Rat:T1622
免疫原
Synthesized peptide derived from human MAP2 (Phospho-Thr1616)
特异性
This antibody detects endogenous phospho levels of MAP2 (Phospho-Thr1616) at Human:T1616, Mouse:T1620, Rat:T1622
稀释度
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010],
组织表达
Brain,Brain cortex,Epithelium,Pancreas,Testis,
细胞定位
Cytoplasm, cytoskeleton . Cell projection, dendrite .
功能
alternative products:Additional isoforms seem to exist,function:The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.,PTM:MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
