产品名称
EPHA1 (Phospho-Tyr605) Rabbit Polyclonal Antibody
别名
Ephrin type-A receptor 1 (hEpha1;EC 2.7.10.1;EPH tyrosine kinase;EPH tyrosine kinase 1;Erythropoietin-producing hepatoma receptor;Tyrosine-protein kinase receptor EPH)
基因名称
EPHA1 EPH EPHT EPHT1
蛋白名称
EPHA1 (Phospho-Tyr605)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
P21709
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P21709/entry
Rat Swissprot Link
Human:Y605, Mouse:Y606
免疫原
Synthesized peptide derived from human EPHA1 (Phospho-Tyr605)
特异性
This antibody detects endogenous phospho levels of EPHA1 (Phospho-Tyr605) at Human:Y605, Mouse:Y606
稀释度
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008],
组织表达
Overexpressed in several carcinomas.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family. Binds with a low affinity to ephrin-A1.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Overexpressed in several carcinomas.,
纯化
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
