产品名称
eEF2 (Phospho-Thr56) Rabbit Polyclonal Antibody
别名
Elongation factor 2 (EF-2)
蛋白名称
Elongation factor 2 (EF-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1938
Human Swissprot No.
P13639
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P13639/entry
Mouse Swissprot No.
P58252
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P58252
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P05197
免疫原
Synthesized phospho derived from human eEF2 (Phospho-Thr56)
特异性
This detects endogenous levels of eEF2 (Phospho-Thr56)
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008],
组织表达
Brain,Cajal-Retzius cell,Epithelium,Hepatocyte,Ovary,Periph
细胞定位
Cytoplasm . Nucleus . Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. .
功能
function:This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.,PTM:Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A.,PTM:Phosphorylation by EF-2 kinase completely inactivates EF-2.,similarity:Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.,subunit:Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
