产品名称
GBRA5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2558
Human Swissprot No.
P31644
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P31644/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/110886
Mouse Swissprot No.
Q8BHJ7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BHJ7
Rat Gene Link
https://www.uniprot.org/uniprot/29707
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P19969
免疫原
Synthesized peptide derived from human GBRA5 AA range: 234-284
特异性
This antibody detects endogenous levels of GBRA5 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008],
细胞定位
Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein. Cell membrane ; Multi-pass membrane protein.
功能
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
