产品名称
Synapsin-1 (phospho Ser553) Rabbit Polyclonal Antibody
别名
SYN1; Synapsin-1; Brain protein 4.1; Synapsin I
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6853
Human Swissprot No.
P17600
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P17600/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20964
Mouse Swissprot No.
O88935
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88935
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24949
Rat Swissprot Link
http://www.uniprot.org/uniprot/P09951
免疫原
Synthesized phospho-peptide around the phosphorylation site of human Synapsin-1 (phospho Ser553)
特异性
Phospho-Synapsin-1 (S553) Polyclonal Antibody detects endogenous levels of Synapsin-1 around the phosphorylation site of S553 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
细胞定位
Cell junction, synapse. Golgi apparatus .
功能
disease:Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.,function:Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.,PTM:Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the synapsin family.,subunit:Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1. Isoform Ib interacts with PRNP.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
