产品名称
Tensin-1 (phospho Tyr1326) Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7145
Human Swissprot No.
Q9HBL0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9HBL0/entry
免疫原
Synthesized phospho-peptide around the phosphorylation site of human Tensin-1 (phospho Tyr1326)
特异性
Phospho-Tensin-1 (Y1326) Polyclonal Antibody detects endogenous levels of Tensin-1 protein only when phosphorylated at Y1326.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],
细胞定位
Cell surface . Cell junction, focal adhesion . Cytoplasm, cytoskeleton . Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
功能
function:May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.,PTM:Rapidly cleaved by calpain II.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subunit:Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
