产品名称
GATA-3 (phospho Ser308) Rabbit Polyclonal Antibody
别名
GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3
蛋白名称
Trans-acting T-cell-specific transcription factor GATA-3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2625
Human Swissprot No.
P23771
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P23771/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14462
Mouse Swissprot No.
P23772
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P23772
免疫原
The antiserum was produced against synthesized peptide derived from human GATA3 around the phosphorylation site of Ser308. AA range:274-323
特异性
Phospho-GATA-3 (S308) Polyclonal Antibody detects endogenous levels of GATA-3 protein only when phosphorylated at S308.
稀释度
WB 1:500-2000 IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009],
组织表达
T-cells and endothelial cells.
功能
disease:Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.,function:Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.,similarity:Contains 2 GATA-type zinc fingers.,tissue specificity:T-cells and endothelial cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
