产品名称
APC1 (phospho Ser688) Rabbit Polyclonal Antibody
别名
ANAPC1; TSG24; Anaphase-promoting complex subunit 1; APC1; Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein
蛋白名称
Anaphase-promoting complex subunit 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64682
Human Swissprot No.
Q9H1A4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H1A4/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17222
Mouse Swissprot No.
P53995
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P53995
免疫原
The antiserum was produced against synthesized peptide derived from human APC1 around the phosphorylation site of Ser688. AA range:654-703
特异性
Phospho-APC1 (S688) Polyclonal Antibody detects endogenous levels of APC1 protein only when phosphorylated at S688.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011],
组织表达
Colon,Epithelium,Ovary,Placenta,
细胞定位
nucleoplasm,anaphase-promoting complex,cytosol,
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;
功能
function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.,similarity:Belongs to the APC1 family.,similarity:Contains 4 PC repeats.,subunit:The APC/C is composed of at least 11 subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
