产品名称
IL-1RI (phospho Tyr496) Rabbit Polyclonal Antibody
别名
IL1R1; IL1R; IL1RA; IL1RT1; Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD antigen CD121a
蛋白名称
Interleukin-1 receptor type 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3554
Human Swissprot No.
P14778
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P14778/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16177
Mouse Swissprot No.
P13504
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P13504
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q02955
免疫原
The antiserum was produced against synthesized peptide derived from human IL-1Ralpha/CD121alpha around the phosphorylation site of Tyr496. AA range:471-520
特异性
Phospho-IL-1RI (Y496) Polyclonal Antibody detects endogenous levels of IL-1RI protein only when phosphorylated at Y496.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013],
组织表达
Expressed in T-helper cell subsets. Preferentially expressed in T-helper 1 (Th1) cells.
细胞定位
Membrane ; Single-pass type I membrane protein . Cell membrane . Secreted .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Cytokine-cytokine receptor interaction;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Hematopoietic cell lineage;
功能
function:Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds IL1RAP.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
