产品名称
SSB (phospho Ser366) Rabbit Polyclonal Antibody
别名
SSB; Lupus La protein; La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6741
Human Swissprot No.
P05455
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P05455/entry
Mouse Swissprot No.
P32067
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P32067
免疫原
The antiserum was produced against synthesized peptide derived from human SSB around the phosphorylation site of Ser366. AA range:341-390
特异性
Phospho-SSB (S366) Polyclonal Antibody detects endogenous levels of SSB protein only when phosphorylated at S366.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Sjogren syndrome antigen B(SSB) Homo sapiens The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014],
组织表达
Epithelium,Liver,Placenta,Skeletal muscle,
信号通路
Systemic lupus erythematosus;
功能
disease:Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.,function:La protein plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3' termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5S, 7S, and 7-2 RNAs.,PTM:Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.,PTM:The N-terminus is blocked.,similarity:Contains 1 HTH La-type RNA-binding domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Interacts with DDX15. May interact with RUFY1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
