产品名称
Calmodulin (phospho Thr80/S82) Rabbit Polyclonal Antibody
别名
CALM1; CALM; CAM; CAM1; CALM2; CAM2; CAMB; CALM3; CALML2; CAM3; CAMC; CAMIII; Calmodulin; CaM
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
801/805/808
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=801
Human Swissprot No.
P62158
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P62158/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12313
Mouse Swissprot No.
P62204
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P62204
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24242
Rat Swissprot Link
http://www.uniprot.org/uniprot/P62161
免疫原
The antiserum was produced against synthesized peptide derived from human Calmodulin around the phosphorylation site of Thr79 and Ser81. AA range:46-95
特异性
Phospho-Calmodulin (T80/S82) Polyclonal Antibody detects endogenous levels of Calmodulin protein only when phosphorylated at T80/S82.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009],
组织表达
Blood,Brain,Cajal-Retzius cell,Fetal brain cortex,Lung,Lymph,Lymphoma,Muscle,Osteosarcoma,P
细胞定位
spindle pole,extracellular region,nucleus,nucleoplasm,cytoplasm,centrosome,cytosol,spindle microtubule,plasma membrane,voltage-gated potassium channel complex,sarcomere,growth cone,vesicle,calcium channel complex,G
信号通路
Calcium;Phosphatidylinositol signaling system;Oocyte meiosis;Vascular smooth muscle contraction;Long-term potentiation;Neurotrophin;Olfactory transduction;Insulin_Receptor;GnRH;Melanogenesis;Alzheimer's disease;Glioma;
功能
function:Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.,miscellaneous:This protein has four functional calcium-binding sites.,PTM:Phosphorylation results in a decreased activity.,PTM:Ubiquitination results in a strongly decreased activity.,similarity:Belongs to the calmodulin family.,similarity:Contains 4 EF-hand domains.,subcellular location:Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.,subunit:Interacts with MYO1C (By similarity). Interacts with CEP97, CEP110, TTN/titin and SRY.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
