BD-PP0907-Gab 1 (phospho Tyr659) Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

Gab 1 (phospho Tyr659) Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PP0907

产品名称

Gab 1 (phospho Tyr659) Rabbit Polyclonal Antibody

别名

GAB1; GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1

类别

常规抗体

基因名称

GAB1

蛋白名称

GRB2-associated-binding protein 1

推荐应用

反应种属

Human,Mouse,Rat

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

2549

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2549

Human Swissprot No.

Q13480

Human Swissprot Link

http://www.uniprot.org/uniprotkb/Q13480/entry

Mouse Gene ID

14388

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14388

Mouse Swissprot No.

Q9QYY0

Mouse Swissprot Link

http://www.uniprot.org/uniprot/Q9QYY0

免疫原

The antiserum was produced against synthesized peptide derived from human GAB1 around the phosphorylation site of Tyr659. AA range:644-674

特异性

Phospho-Gab 1 (Y659) Polyclonal Antibody detects endogenous levels of Gab 1 protein only when phosphorylated at Y659.

稀释度

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

预测分子量

76kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],

组织表达

Testis,Whole embryo,

细胞定位

cytosol,

信号通路

ErbB_HER;Neurotrophin;Renal cell carcinoma;

功能

function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Enzyme-Linked Immunosorbent Assay （Phospho-ELISA） for Immunogen Phosphopeptide （Phospho-left） and Non-Phosphopeptide （Phospho-right）, using GAB1 （Phospho-Tyr659） Antibody

Immunofluorescence analysis of HepG2 cell, using GAB1 （Phospho-Tyr659） Antibody. The lane on the right is blocked with the GAB1 （Phospho-Tyr659） peptide.

Immunohistochemistry analysis of paraffin-embedded human breast cancer, using GAB1 （Phospho-Tyr659） Antibody. The picture on the right is blocked with the GAB1 （Phospho-Tyr659） peptide.

Western blot analysis of GAB1 （Phospho-Tyr659） Antibody. The lane on the right is blocked with the GAB1 （Phospho-Tyr659） peptide.

Western Blot analysis of 3T3 cells using Phospho-Gab 1 （Y659） Polyclonal Antibody