产品名称
SDPR Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8436
Human Swissprot No.
O95810
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95810/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20324
Mouse Swissprot No.
Q63918
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q63918
Rat Gene Link
https://www.uniprot.org/uniprot/316384
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q66H98
免疫原
Synthesized peptide derived from human SDPR AA range: 129-179
特异性
This antibody detects endogenous levels of SDPR at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009],
组织表达
Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
细胞定位
Cytoplasm, cytosol . Membrane, caveola . Localizes in the caveolae in a caveolin-dependent manner. .
功能
function:May play a role in targeting PRKCA to caveolae.,induction:Up-regulated in asyncronously growing fibroblasts following serum deprivation but not following contact inhibition. Down-regulated during synchronous cell cycle re-entry.,miscellaneous:Binds phosphatidylserine (PS) in a calcium-independent manner. PS-binding is inhibited by phosphotidic acid and phosphatidylinositol. Does not bind phosphatidylcholine.,PTM:Phosphorylated on Ser residues.,PTM:The N-terminus is blocked.,similarity:Belongs to the PTRF/SDPR family.,subcellular location:Colocalizes with CAV1 to caveolae.,subunit:Binds to PRKCA in the presence of phosphatidylserine (By similarity). Interacts with MURC; this augments the transactivation of NPPA by MURC.,tissue specificity:Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
