产品名称
TOB1 (phospho Ser164) Rabbit Polyclonal Antibody
别名
TOB1; TOB; TROB1; Protein Tob1; Transducer of erbB-2 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10140
Human Swissprot No.
P50616
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P50616/entry
Mouse Swissprot No.
Q61471
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61471
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q8R5K6
免疫原
The antiserum was produced against synthesized peptide derived from human TOB1 around the phosphorylation site of Ser164. AA range:130-179
特异性
Phospho-TOB1 (S164) Polyclonal Antibody detects endogenous levels of TOB1 protein only when phosphorylated at S164.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],
细胞定位
Cytoplasm . Nucleus . Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. .
功能
function:Anti-proliferative protein that interacts with the erbB-2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors.,PTM:Phosphorylated on Ser and Thr residues.,similarity:Belongs to the BTG family.,subunit:Interacts with CNOT7.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
