产品名称
p47-phox (phospho Ser345) Rabbit Polyclonal Antibody
别名
NCF1; NOXO2; SH3PXD1A; Neutrophil cytosol factor 1; NCF-1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3
蛋白名称
Neutrophil cytosol factor 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=653361
Human Swissprot No.
P14598
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P14598/entry
Mouse Swissprot No.
Q09014
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q09014
免疫原
The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser345. AA range:311-360
特异性
Phospho-p47-phox (S345) Polyclonal Antibody detects endogenous levels of p47-phox protein only when phosphorylated at S345.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008],
组织表达
Detected in peripheral blood monocytes and neutrophils (at protein level).
细胞定位
Cytoplasm, cytosol . Membrane ; Peripheral membrane protein ; Cytoplasmic side .
信号通路
Chemokine;Fc gamma R-mediated phagocytosis;Leukocyte transendothelial migration;
功能
disease:Defects in NCF1 are the cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 1 (CGD1) [MIM:233700]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,function:NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).,online information:NCF1 deficiency database,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with NOXA1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
