BD-PP0751-Cdc37 (phospho Ser13) Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

Cdc37 (phospho Ser13) Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PP0751

产品名称

Cdc37 (phospho Ser13) Rabbit Polyclonal Antibody

别名

CDC37; CDC37A; Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37

类别

常规抗体

基因名称

CDC37

蛋白名称

Hsp90 co-chaperone Cdc37

推荐应用

反应种属

Human,Mouse,Rat

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

11140

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11140

Human Swissprot No.

Q16543

Human Swissprot Link

http://www.uniprot.org/uniprotkb/Q16543/entry

Mouse Gene ID

12539

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12539

Mouse Swissprot No.

Q61081

Mouse Swissprot Link

http://www.uniprot.org/uniprot/Q61081

Rat Gene ID

114562

Rat Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114562

Rat Swissprot No.

Q63692

Rat Swissprot Link

http://www.uniprot.org/uniprot/Q63692

免疫原

The antiserum was produced against synthesized peptide derived from human CDC37 around the phosphorylation site of Ser13. AA range:1-50

特异性

Phospho-Cdc37 (S13) Polyclonal Antibody detects endogenous levels of Cdc37 protein only when phosphorylated at S13.

稀释度

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

预测分子量

44kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008],

组织表达

Lymph,Placenta,

细胞定位

Cytoplasm .

信号通路

PI3K/Akt

功能

function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.,PTM:Constitutively sumoylated by UBE2I.,similarity:Belongs to the CDC37 family.,subunit:Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunohistochemistry analysis of paraffin-embedded human placenta, using CDC37 （Phospho-Ser13） Antibody. The picture on the right is blocked with the phospho peptide.

Western blot analysis of lysates from HUVEC cells, using CDC37 （Phospho-Ser13） Antibody. The lane on the right is blocked with the phospho peptide.

Western Blot analysis of 3T3 cells using Phospho-Cdc37 （S13） Polyclonal Antibody

Immunohistochemical analysis of paraffin-embedded Human lung cancer. Antibody was diluted at 1:100（4°,overnight）. High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl （right） obtaned from antibody was pre-absorbed by immunogen peptide.