产品名称
EPPI Rabbit Polyclonal Antibody
基因名称
EPPIN SPINLW1 WAP7 WFDC7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/100526773
Human Swissprot No.
O95925
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95925/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/75526
Mouse Swissprot No.
Q9DA01
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9DA01
Rat Gene Link
https://www.uniprot.org/uniprot/685161
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/D4A2Z2
免疫原
Synthesized peptide derived from human EPPI AA range: 55-105
特异性
This antibody detects endogenous levels of EPPI at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014],
组织表达
In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells.
细胞定位
[Isoform 1]: Secreted. Cell surface. Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.
功能
similarity:Contains 1 BPTI/Kunitz inhibitor domain.,similarity:Contains 1 WAP domain.,tissue specificity:Expressed in epididymis and testis.,tissue specificity:Ubiquitously expressed, but the highest levels are found in epididymis, testis and trachea.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
