产品名称
IF122 Rabbit Polyclonal Antibody
基因名称
IFT122 SPG WDR10 WDR140
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55764
Human Swissprot No.
Q9HBG6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HBG6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/81896
Mouse Swissprot No.
Q6NWV3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6NWV3
免疫原
Synthesized peptide derived from human IF122 AA range: 956-1006
特异性
This antibody detects endogenous levels of IF122 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],
组织表达
Expressed in many tissues. Predominant expression in testis and pituitary.
细胞定位
Cell projection, cilium . Cytoplasm, cytoskeleton, cilium basal body . Localizes to photoreceptor connecting cilia. .
功能
similarity:Contains 7 WD repeats.,tissue specificity:Expressed in many tissues. Predominant expression in testis and pituitary.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
