产品名称
IL-13Rα1 (phospho Tyr405) Rabbit Polyclonal Antibody
别名
IL13RA1; IL13R; IL13RA; Interleukin-13 receptor subunit alpha-1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Cancer/testis antigen 19; CT19; CD antigen CD213a1
蛋白名称
Interleukin-13 receptor subunit alpha-1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3597
Human Swissprot No.
P78552
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P78552/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16164
Mouse Swissprot No.
O09030
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O09030
免疫原
The antiserum was produced against synthesized peptide derived from human IL-13R alpha1 around the phosphorylation site of Tyr405. AA range:371-420
特异性
Phospho-IL-13Rα1 (Y405) Polyclonal Antibody detects endogenous levels of IL-13Rα1 protein only when phosphorylated at Y405.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
细胞定位
Membrane; Single-pass type I membrane protein.
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Binds IL13 with a low affinity. Together with IL4R-alpha can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for IL4 signaling, but cannot replace the function of gamma C in allowing enhanced IL2 binding activity.,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily.,subunit:Interleukin 13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1.,tissue specificity:Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
