产品名称
Annexin II (phospho Ser26) Rabbit Polyclonal Antibody
别名
ANXA2; ANX2; ANX2L4; CAL1H; LPC2D; Annexin A2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=302
Human Swissprot No.
P07355
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P07355/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12306
Mouse Swissprot No.
P07356
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P07356
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56611
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q07936
免疫原
Synthesized phospho-peptide around the phosphorylation site of human Annexin II (phospho Ser26)
特异性
Phospho-Annexin II (S26) Polyclonal Antibody detects endogenous levels of Annexin II protein only when phosphorylated at S26.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Brain,Colon,Colon adenocarcinoma,Epithelium,Osteosarcoma,Pancreas,Placenta,Prostate,Skin,Te
细胞定位
Secreted, extracellular space, extracellular matrix, basement membrane . Melanosome . In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
功能
domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,function:Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.,miscellaneous:It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis.,online information:Red velvet - Issue 86 of September 2007,PTM:Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.,similarity:Belongs to the annexin family.,similarity:Contains 4 annexin repeats.,subcellular location:In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.,subunit:Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
