产品名称
TPH2 (phospho Ser19) Rabbit Polyclonal Antibody
别名
TPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
蛋白名称
Tryptophan 5-hydroxylase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=121278
Human Swissprot No.
Q8IWU9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IWU9/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=216343
Mouse Swissprot No.
Q8CGV2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CGV2
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=317675
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q8CGU9
免疫原
Synthesized phospho-peptide around the phosphorylation site of human TPH2 (phospho Ser19)
特异性
Phospho-TPH2 (S19) Polyclonal Antibody detects endogenous levels of TPH2 protein only when phosphorylated at S19.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016],
细胞定位
cytosol,neuron projection,
信号通路
Tryptophan metabolism;
功能
catalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,disease:Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,tissue specificity:Brain specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
