BD-PP0455

FANCG (phospho Ser383) Rabbit Polyclonal Antibody

FANCG; XRCC9; Fanconi anemia group G protein; Protein FACG; DNA repair protein XRCC9

常规抗体

FANCG

Fanconi anemia group G protein

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

2189

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2189

O15287

http://www.uniprot.org/uniprotkb/O15287/entry

Q9EQR6

http://www.uniprot.org/uniprot/Q9EQR6

Synthesized phospho-peptide around the phosphorylation site of human FANCG (phospho Ser383)

Phospho-FANCG (S383) Polyclonal Antibody detects endogenous levels of FANCG protein only when phosphorylated at S383.

WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

69kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008],

Highly expressed in testis and thymus. Found in lymphoblasts.

Nucleus . Cytoplasm . The major form is nuclear. The minor form is cytoplasmic.

disease:Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.,function:DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.,similarity:Contains 4 TPR repeats.,subcellular location:The major form is nuclear. The minor form is cytoplasmic.,subunit:Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients.,tissue specificity:Highly expressed in testis and thymus. Found in lymphoblasts.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.