产品名称
RGS16 (phospho Tyr168) Rabbit Polyclonal Antibody
别名
RGS16; RGSR; Regulator of G-protein signaling 16; RGS16; A28-RGS14P; Retinal-specific RGS; RGS-r; hRGS-r; Retinally abundant regulator of G-protein signaling
蛋白名称
Regulator of G-protein signaling 16
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6004
Human Swissprot No.
O15492
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O15492/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19734
Mouse Swissprot No.
P97428
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97428
Rat Swissprot Link
http://www.uniprot.org/uniprot/P56700
免疫原
The antiserum was produced against synthesized peptide derived from human RGS16 around the phosphorylation site of Tyr168. AA range:141-190
特异性
Phospho-RGS16 (Y168) Polyclonal Antibody detects endogenous levels of RGS16 protein only when phosphorylated at Y168.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008],
组织表达
Abundantly expressed in retina with lower levels of expression in most other tissues.
细胞定位
Membrane ; Lipid-anchor .
功能
function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade.,PTM:Palmitoylated on Cys-2 and/or Cys-12.,PTM:Phosphorylation on Tyr-168 upon EGFR stimulation. Enhanced GTPase accelerating (GAP) activity on G(i)-alpha.,similarity:Contains 1 RGS domain.,tissue specificity:Abundantly expressed in retina with lower levels of expression in most other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
