产品名称
TIS11B (phospho Ser92) Rabbit Polyclonal Antibody
别名
ZFP36L1; BERG36; BRF1; ERF1; RNF162B; TIS11B; Zinc finger protein 36; C3H1 type-like 1; Butyrate response factor 1; EGF-response factor 1; ERF-1; Protein TIS11B
蛋白名称
Zinc finger protein 36 C3H1 type-like 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=677
Human Swissprot No.
Q07352
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q07352/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12192
Mouse Swissprot No.
P23950
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P23950
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29344
Rat Swissprot Link
http://www.uniprot.org/uniprot/P17431
免疫原
The antiserum was produced against synthesized peptide derived from human TISB around the phosphorylation site of Ser92. AA range:58-107
特异性
Phospho-TIS11B (S92) Polyclonal Antibody detects endogenous levels of TIS11B protein only when phosphorylated at S92.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
组织表达
Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009). Expressed in osteoblasts (PubMed:15465005).
细胞定位
Nucleus . Cytoplasm . Cytoplasmic granule . Cytoplasm, P-body . Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (By similarity). Component of cytoplasmic stress granules (PubMed:15967811). Localizes in processing bodies (PBs) (PubMed:17369404). .
功能
function:Probable regulatory protein involved in regulating the response to growth factors.,similarity:Contains 2 C3H1-type zinc fingers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
