BD-PP0379

CD40 (phospho Thr254) Rabbit Polyclonal Antibody

CD40; TNFRSF5; Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD antigen CD40

常规抗体

CD40

Tumor necrosis factor receptor superfamily member 5

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

958

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=958

P25942

http://www.uniprot.org/uniprotkb/P25942/entry

21939

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21939

P27512

http://www.uniprot.org/uniprot/P27512

The antiserum was produced against synthesized peptide derived from human TNFRSF5 around the phosphorylation site of Thr254. AA range:220-269

Phospho-CD40 (T254) Polyclonal Antibody detects endogenous levels of CD40 protein only when phosphorylated at T254.

WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

30kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIG

B-cells and in primary carcinomas.

[Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.

Cytokine-cytokine receptor interaction;Cell adhesion molecules (CAMs);Toll_Like;Intestinal immune network for IgA production;Asthma;Autoimmune thyroid disease;Systemic lupus erythematosus;Allograft rejection;Primary immunodeficiency;Viral myocarditis;

alternative products:Additional isoforms seem to exist,disease:Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3) [MIM:606843]. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.,function:Receptor for TNFSF5/CD40LG.,online information:CD40 entry,online information:CD40 mutation db,similarity:Contains 4 TNFR-Cys repeats.,subunit:Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:B-cells and in primary carcinomas.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.