产品名称
CD28 (phospho Tyr218) Rabbit Polyclonal Antibody
别名
CD28; T-cell-specific surface glycoprotein CD28; TP44; CD antigen CD28
蛋白名称
T-cell-specific surface glycoprotein CD28
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=940
Human Swissprot No.
P10747
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P10747/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12487
Mouse Swissprot No.
P31041
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P31041
免疫原
The antiserum was produced against synthesized peptide derived from human CD28 around the phosphorylation site of Tyr218. AA range:171-220
特异性
Phospho-CD28 (Y218) Polyclonal Antibody detects endogenous levels of CD28 protein only when phosphorylated at Y218.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011],
组织表达
Expressed in T-cells and plasma cells, but not in less mature B-cells.
细胞定位
Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface .
信号通路
Cell adhesion molecules (CAMs);T_Cell_Receptor;Intestinal immune network for IgA production;Type I diabetes mellitus;Autoimmune thyroid disease;Systemic lupus erythematosus;Allograft rejection;Graft-versus-host disease;Viral myocarditis;
功能
function:Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.,online information:CD28 entry,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.,tissue specificity:Expressed in T-cells and plasma cells, but not in less mature B-cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
