产品名称
MPP4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/58538
Human Swissprot No.
Q96JB8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96JB8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/227157
Mouse Swissprot No.
Q6P7F1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P7F1
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QYH1
免疫原
Synthesized peptide derived from human MPP4 AA range: 388-438
特异性
This antibody detects endogenous levels of MPP4 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],
组织表达
Expressed in the retina (at protein level). Highly expressed in the retina. Lower amounts are detected in brain, testis, ARPE-19, RPE/choroid and fetal eye. Isoform 5 is retina-specific.
细胞定位
Cytoplasm . Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ).
功能
function:May play a role in retinal photoreceptors development.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 L27 domains.,subcellular location:Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ).,subunit:Interacts with MPDZ. May interact with GRIA2 (By similarity). Forms a complex with CRB1 and MPP5.,tissue specificity:Expressed in the retina (at protein level). Highly expressed in the retina. Lower amounts are detected in brain, testis, ARPE-19, RPE/choroid and fetal eye. Isoform 5 is retina-specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
