产品名称
CD19 (phospho Tyr531) Rabbit Polyclonal Antibody
别名
CD19; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD antigen CD19
蛋白名称
B-lymphocyte antigen CD19
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=930
Human Swissprot No.
P15391
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P15391/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12478
Mouse Swissprot No.
P25918
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P25918
免疫原
The antiserum was produced against synthesized peptide derived from human CD19 around the phosphorylation site of Tyr531. AA range:501-550
特异性
Phospho-CD19 (Y531) Polyclonal Antibody detects endogenous levels of CD19 protein only when phosphorylated at Y531.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008],
组织表达
Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701).
细胞定位
Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .
信号通路
Hematopoietic cell lineage;B_Cell_Antigen;Primary immunodeficiency;
功能
disease:Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].,function:Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.,online information:CD19 mutation db,PTM:Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
