产品名称
Tensin-2 (phospho Tyr483) Rabbit Polyclonal Antibody
别名
TENC1; KIAA1075; TNS2; Tensin-like C1 domain-containing phosphatase; C1 domain-containing phosphatase and tensin homolog; C1-TEN; Tensin-2
蛋白名称
Tensin-like C1 domain-containing phosphatase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23371
Human Swissprot No.
Q63HR2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q63HR2/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=209039
Mouse Swissprot No.
Q8CGB6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CGB6
免疫原
Synthesized phospho-peptide around the phosphorylation site of human Tensin-2 (phospho Tyr483)
特异性
Phospho-Tensin-2 (Y483) Polyclonal Antibody detects endogenous levels of Tensin-2 protein only when phosphorylated at Y483.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008],
组织表达
Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.
细胞定位
Cell junction, focal adhesion . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427). .
功能
function:Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subcellular location:Detected at the end of actin stress fibers.,subunit:Interacts with AXL.,tissue specificity:Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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