产品名称
FA11 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2160
Human Swissprot No.
P03951
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P03951/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/109821
Mouse Swissprot No.
Q91Y47
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91Y47
免疫原
Synthesized peptide derived from human FA11 AA range: 491-540
特异性
This antibody detects endogenous levels of FA11 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008],
组织表达
Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
功能
catalytic activity:Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.,disease:Defects in F11 are the cause of F11 deficiency [MIM:612416]; also called plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a blood coagulation abnormality occurring in high frequency in Ashkenazi jews. F11-deficient patients are prone to excessive bleeding after haemostatic challenge.,function:Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.,online information:Factor XI entry,PTM:Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.,similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 4 apple domains.,subunit:Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond.,tissue specificity:Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
