产品名称
PI 3-kinase p85β (phospho Tyr464) Rabbit Polyclonal Antibody
别名
p85; p85 beta; p85-BETA; P85B; P85B_HUMAN; Phosphatidylinositol 3 kinase; Phosphatidylinositol 3 kinase regulatory beta subunit; Phosphatidylinositol 3 kinase regulatory subunit beta; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2; Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta); Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-kinase regulatory beta subunit; Phosphatidylinositol 3-kinase regulatory subunit beta; Phosphoinositide 3 kinase regulatory subunit 2 (beta); Phosphoinositide 3 kinase regulatory subunit 2; Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta); Phosphoinositide 3 kinase regulatory subunit polypeptide 2; Phosphoinositide 3 kinase, regulatory subunit 2 (beta); Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta); PI3 kinase p85 beta subunit; PI3 kinase p85 subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K; PI3K regulatory subunit beta; PIK3R 2; PIK3R2; polypeptide 2 (p85 beta); PtdIns 3 kinase p85 beta; PtdIns-3-kinase p85-beta; PtdIns-3-kinase regulatory subunit beta; PtdIns-3-kinase regulatory subunit p85-beta.
蛋白名称
Phosphatidylinositol 3-kinase regulatory subunit beta
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5296
Human Swissprot No.
O00459
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O00459/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18709
Mouse Swissprot No.
O08908
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08908
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63788
免疫原
Synthesized phospho-peptide around the phosphorylation site of human PI 3-kinase p85β (phospho Tyr464)
特异性
Phospho-PI 3-kinase p85β (Y464) Polyclonal Antibody detects endogenous levels of PI 3-kinase p85β protein only when phosphorylated at Y464.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012],
组织表达
Brain,Epithelium,Kidney,Placenta,
细胞定位
nucleus,cytosol,phosphatidylinositol 3-kinase complex,
信号通路
Regulates Angiogenesis; Regulation_Microtubule; Regulation of Actin Dynamics; SAPK_JNK; Stem cell pathway; Insulin Receptor; ErbB/HER; AMPK; mTOR; B Cell Receptor; Adherens_Junction
功能
function:Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.,similarity:Belongs to the PI3K p85 subunit family.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,subunit:Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
