产品名称
KDIS Rabbit Polyclonal Antibody
基因名称
KIDINS220 ARMS KIAA1250
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57498
Human Swissprot No.
Q9ULH0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ULH0/entry
Rat Gene Link
https://www.uniprot.org/uniprot/116478
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EQG6
免疫原
Synthesized peptide derived from human KDIS AA range: 1023-1073
特异性
This antibody detects endogenous levels of KDIS at Human/Rat
宿主
Polyclonal, Rabbit,IgG
组织表达
Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
细胞定位
Membrane ; Multi-pass membrane protein . Late endosome . Localized at late endosome before or after nerve growth factor (NGF) stimulation.
功能
domain:The transmembrane domain mediates interaction with NTRK1.,function:Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.,PTM:Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF).,similarity:Contains 12 ANK repeats.,subunit:Interacts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Can form a ternary complex with NGFR and NTRK1 and this complex is affected by the expression levels of KIDINS220/ARMS. An increase in KIDINS220/ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with SNTA1 and SNTB2 and binds to their PDZ domains. Interacts with EPHA4 and PRKD1.,tissue specificity:Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
