产品名称
MAT2B Rabbit Polyclonal Antibody
基因名称
MAT2B TGR MSTP045 Nbla02999 UNQ2435/PRO4995
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/27430
Human Swissprot No.
Q9NZL9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NZL9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/108645
Mouse Swissprot No.
Q99LB6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99LB6
Rat Gene Link
https://www.uniprot.org/uniprot/683630
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U2R0
免疫原
Synthesized peptide derived from human MAT2B AA range: 23-73
特异性
This antibody detects endogenous levels of MAT2B at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012],
细胞定位
intracellular,nucleus,mitochondrion,cytosol,methionine adenosyltransferase complex,extracellular exosome,
功能
function:Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition.,miscellaneous:Its expression in hepatoma cell lines may lead to increase DNA synthesis and thereby participate to cell proliferation.,pathway:Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.,similarity:Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.,subunit:Heterotetramer composed of 2 catalytic alpha subunits (alpha and alpha') (MAT2A) and 1 copy of beta subunit (MAT2B).,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
