产品名称
GBRT Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55879
Human Swissprot No.
Q9UN88
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UN88/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/57249
Mouse Swissprot No.
Q9JLF1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JLF1
免疫原
Synthesized peptide derived from human GBRT AA range: 317-367
特异性
This antibody detects endogenous levels of GBRT at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009],
细胞定位
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
功能
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
