产品名称
HBG1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3047
Human Swissprot No.
P69891
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P69891/entry
免疫原
Synthesized peptide derived from human HBG1 AA range: 34-84
特异性
This antibody detects endogenous levels of HBG1 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008],
细胞定位
cytosol,hemoglobin complex,
功能
developmental stage:Expressed until four or five weeks after birth.,disease:Some gamma variants can cause severe jaundice and cyanosis in premature and new born babies.,function:Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.,online information:Human hemoglobin variants and thalassemias,PTM:Acetylation of Gly-2 converts Hb F to the minor Hb F1.,similarity:Belongs to the globin family.,subunit:Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F). In the case of deletions affecting one or more of the alpha chains the excess gamma chains form homotetramers that exhibit neither Bohr effect nor heme-heme cooperativity (hemoglobin Bart's).,tissue specificity:Red blood cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
