产品名称
Gab 1 (phospho Tyr627) Rabbit Polyclonal Antibody
别名
GAB1; GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1
蛋白名称
GRB2-associated-binding protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2549
Human Swissprot No.
Q13480
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13480/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14388
Mouse Swissprot No.
Q9QYY0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QYY0
免疫原
The antiserum was produced against synthesized peptide derived from human GAB1 around the phosphorylation site of Tyr627 AA range:611-643
特异性
Phospho-Gab 1 (Y627) Polyclonal Antibody detects endogenous levels of Gab 1 protein only when phosphorylated at Y627.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
组织表达
Testis,Whole embryo,
信号通路
ErbB_HER;Neurotrophin;Renal cell carcinoma;
功能
function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
