产品名称
BHE40 Rabbit Polyclonal Antibody
基因名称
BHLHE40 BHLHB2 DEC1 SHARP2 STRA13
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8553
Human Swissprot No.
O14503
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O14503/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20893
Mouse Swissprot No.
O35185
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35185
Rat Gene Link
https://www.uniprot.org/uniprot/79431
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O35780
免疫原
Synthesized peptide derived from human BHE40 AA range: 229-279
特异性
This antibody detects endogenous levels of BHE40 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. [provided by RefSeq, Feb 2014],
组织表达
Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.
细胞定位
Cytoplasm . Nucleus . Predominantly localized in the nucleus (PubMed:11278694). .
功能
function:May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway.,PTM:Ubiquitinated; which may lead to proteasomal degradation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 Orange domain.,subunit:Able to homodimerize or heterodimerize with TCF3/E47. Interacts with ubiquitin-conjugating enzyme UBE2I/UBC9.,tissue specificity:Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
