产品名称
LFTY2 Rabbit Polyclonal Antibody
基因名称
LEFTY2 EBAF LEFTA LEFTYA TGFB4 PSEC0024
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7044
Human Swissprot No.
O00292
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O00292/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/320202
Mouse Swissprot No.
P57785
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P57785
免疫原
Synthesized peptide derived from human LFTY2 AA range: 205-255
特异性
This antibody detects endogenous levels of LFTY2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016],
组织表达
Mesenchymal cells of the endometrial stroma.
功能
developmental stage:Transiently expressed before and during menstrual bleeding.,disease:Defects in LEFTY2 are the cause of left-right axis malformations (L-R axis malformation) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.,function:Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.,PTM:The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.,sequence caution:Authors have revised their sequence, but have not submitted the revised DNA sequence.,similarity:Belongs to the TGF-beta family.,tissue specificity:Mesenchymal cells of the endometrial stroma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
