产品名称
GGCT Rabbit Polyclonal Antibody
蛋白名称
Gamma-glutamylcyclotransferase (EC 2.3.2.4) (Cytochrome c-releasing factor 21)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75223
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75223/entry
Mouse Swissprot No.
Q9D7X8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D7X8
免疫原
Synthesized peptide derived from part region of human protein
特异性
GGCT Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
组织表达
Kidney,Lung,Skeletal muscle,Skin,Urinary bladder,
细胞定位
cytosol,extracellular exosome,
信号通路
Glutathione metabolism;
功能
catalytic activity:(Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.,function:Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.,induction:By geranylgeraniol.,similarity:Belongs to the gamma-glutamylcyclotransferase family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
