产品名称
RGRF1 Rabbit Polyclonal Antibody
基因名称
RASGRF1 CDC25 GNRP GRF1
蛋白名称
Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q13972
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13972/entry
Mouse Swissprot No.
P27671
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P27671
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P28818
免疫原
Synthesized peptide derived from part region of human protein
特异性
RGRF1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009],
细胞定位
intracellular,cytosol,plasma membrane,growth cone,neuron projection,
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Focal adhesion;
功能
domain:The DH (DBL-homology) domain mediates interaction with RASGRF2.,function:Promotes the exchange of Ras-bound GDP by GTP.,PTM:Ubiquitinated.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 IQ domain.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,similarity:Contains 2 PH domains.,subunit:Homooligomer and heterooligomer with RASGRF2. Interacts with USP8, thereby regulating its stability.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
