产品名称
GGCT Rabbit Polyclonal Antibody
蛋白名称
Gamma-glutamylcyclotransferase (EC 2.3.2.4) (Cytochrome c-releasing factor 21)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O75223
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75223/entry
Mouse Swissprot No.
Q9D7X8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D7X8
免疫原
Synthesized peptide derived from part region of human protein
特异性
GGCT Polyclonal Antibody detects endogenous levels of protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010],
组织表达
Kidney,Lung,Skeletal muscle,Skin,Urinary bladder,
细胞定位
cytosol,extracellular exosome,
信号通路
Glutathione metabolism;
功能
catalytic activity:(Gamma-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.,function:Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.,induction:By geranylgeraniol.,similarity:Belongs to the gamma-glutamylcyclotransferase family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
